This research will establish prevalence data of nonalcoholic fatty liver disease (NAFLD) and the frequency of a specific indicator of genetic risk, the PNPLA3 allele, in Tucson, AZ. This project will accomplish this by assessing relationships between the PNPLA3 genotype, liver fat, and dietary behaviors in Mexican-origin adults, and evaluating the knowledge, attitudes, and beliefs of NAFLD risk, including genetic risk, held by Mexican-origin men and women. This project is funded by the American Cancer Society through its Institutional Cancer Research Center Grant.