Two and a half billion people around the world are at risk from the mosquito-borne viral disease, dengue. Reducing risk by eliminating the mosquitoes that carry the virus is the only way to prevent disease. For this project we are modeling a novel intervention strategy developed by the Centers for Disease Control and Prevention in Puerto Rico using ‘field’ data collected at the UA’s Biosphere-2. Modeling this public health intervention its effectiveness can be model compared to other strategies, in other locations, and under alternative climate scenarios.